Unfortunately, the base radio does not have pre amp outputs. It is also part of the GMLAN system, so if you replace it, you will lose On-Star, Parking Assist, warning chimes, blinker clicking, and maybe more. There are adaptors out there that retain some or all of these features but even Crutchfield (who sells aftermarket radios) does not recommend replacing the factory unit.
I did change out the speakers on mine (the factory ones are just one-way paper cones in plastic baskets- total garbage) with some Clarion units. They added a lot of upper range but the bottom is still lacking and they don't go very loud (which is OK for me). My next project is a subwoofer, though I'm not yet sure where I'll put it.