I was able to change the plugs on my wife's 2007 Acadia (did it @100k & 200K). The rears are a pain, but I didn't have to remove the upper intake plenum, but I needed 3 swivels and 3 extensions to get to the plugs. Also, the coil packs are not fun to remove, but a 10mm socket and a mirror will aid.
I think it took me ~4hrs for the whole job (all 6 spark plugs) with the majority of the time on the rear 3, for the first time. The second time, I was able to finish in 2 hrs - since I knew what needed to be done.
Good luck,
-Bill